Paracetamol disintegration time usp. Dec 21, 2020 · Results.

Paracetamol disintegration time usp 9 to 63. Jan 19, 2011 · The mean time to complete disintegration was five times faster for FD-APAP compared with standard acetaminophen (12. 5‒8) In this study, we aimed to evaluate the clinical disintegra-tion time of 17 ODTs that are currently available for clinical use in Japan. 0%. Evaluation of quality of paracetamol 500mg tablet manufactured by four local manufacturers in Ethiopia and marketed at Bahir Dar, Ethiopia By: Tessema Kassahun Gebeyehu Pharmacist: Ethiopian pharmaceutical supply Agency [EPSA] Abstract Background: Acetaminophen is a widely used over-the-counter analgesic, antipyretic and a mild anti-inflammatory drug. 63 seconds to351±9. 09 Disintegration Test, and USP <701> Disintegration can be used as interchangeable in the ICH regions subject to the conditions detailed below. While one brand exceeded the allowed disintegration time by about 5 minutes. 8ph phosphate buffer, at 50 rpm, 37ᵒc for 45 minutes, 5ml of samples were withdrawn at time intervals of 5, 15, 30, 45 minutes, which was replaced by fresh equal volume of Journal of applied science and environmental management, 2024. The overall disintegration time of all brands of paracetamol is in the range from 1-4 mins. 1 The materials should not sorb, react, or interfere with the specimen being Change to read: tested. Apparatus B— The apparatus 1 consists of a basket-rack assembly, a 1000-mL, low-form beaker for the immersion fluid, a thermostatic arrangement for heating the fluid between 35 and 39, and a device for raising and lowering the basket in the immersion fluid at a constant frequency rate between 29 and 32 cycles per minute through a distance of not less than 53 mm and not more than 57 mm. Except for P2, all brands met the BP criterion for paracetamol, with quantities ranging from 87. 02 minutes. Dissolution study: the study was carried out using type-2 paddle type usp apparatus. Feb 1, 1998 · The disintegration time in 0. 1 N HCl, Phosphate buffer pH 5. . The currently accepted in vitro testing regimen for ODTs is the standard United States Pharmacopeia (USP) test for disintegration of immediate release tablets, which requires a large volume along with repeated submergence of the dosage form within the Jun 9, 2019 · Under all the storage conditions paracetamol tablets show an increase in disintegration time ranging from 9. The medicated Paracetamol lozenges were evaluated for various physiochemical parameters like Friability, weight variation test, hardness test, dissolution test, and disintegration test Results . The disintegration time, dissolution profile and content uniformity were performed in three different mediums such as 0. 70 N, 0. To be in compliance with USP standards , the tablet must disintegrate and all particles must pass through the 10 mesh screen in the time specified. The medicated Paracetamol lozenges were evaluated for various physiochemical parameters like Friability, weight variation test, hardness test, dissolution test, and disintegration test the disintegration basket containing 900mlof phosphate buffer pH 6. Paracetamol tablet was expected to disintegrate within 15 minutes. 69 minutes while the disintegration time for Brand B is 7. 8 and phosphate buffer pH 6. 07 to 0. USP cates that it meets USP Dissolution Test 3. Results Two reference (R1 and R2) and seven generic (G1-G7) brands were commercially available. Complete disintegration isertures and with a wire diameter of 0. Methods: The general quality parameters of these tablets like weight variation, hardness, thickness, diameter, friability, disintegration time and also dissolution time were evaluated according to the established protocols. From the results, it was observed that all the brands of paracetamol have passed the tests and met the specifications of USP. According to BP specifications, conventional uncoated tablets were expected to disintegrate within 15 min. Download General Chapter <701> Disintegration | En español; Download the Disintegration PDG Sign-Off Cover Page: October 2, 2018, Rev1, Corr1; 30-Oct-2007, Rev. Akshay et al. Nov 24, 2015 · A: USP offers both documentary and physical reference standards to support dosage form performance testing. Table 3. 5 cm from the bottom of the beaker. Testing conditions for specific dosage forms are outside the scope of the harmonization of this chapter. descends to not less than 25 mm from the bottom of the vessel on the downward stroke. The mean time to onset of disintegration was significantly faster with FD-APAP than with standard acetaminophen (P < 0. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the commercially available tablet brands of paraceta-mol Results . 44 ± 0. Weight variation and hardness value requirement was complied by all brands . , 2011). Title: Guidance for Sep 19, 2020 · Paracetamol tablet was expected to disintegrate within 15 minutes. For the purposes of this test, disintegration doesplate is a woven stainless steel wire cloth, which not imply complete solution of the unit or even ofhas a plain square weave with 1. Feb 2, 2024 · Disintegration Time: Uncoated tablets: 15 min (BP, IP), 30 min (USP) Film-coated: 30 min (BP), others coated tablets 60 min: Sugar-coated: 60 min (BP) Effervescent tablets <5 min (BP, IP) Dispersible tablets <3 min (BP, IP) Enteric-coated tablets: With 0. pletely. 46 to 1. Disintegration test of paracetamol tablets. Compliance with the limits on Disintegration stated in the individual monographs is required. Perform the test in triplicate and note down the average time taken by the tablets for disintegration. Furthermore, Sahle and others [16] conducted an exclusively experimental study that used BP/USP to Various studies conducted in Malaysia, Palestine, Pakistan, Bangladesh, and India have investigated brands of paracetamol and fulfilled the requirements on USP for disintegration time. 1. The USP specifications for assay are that the drug content should Dec 21, 2020 · The tablets were evaluated to check if they comply with the specifications of USP (United States Pharmacopeia). Methods: The general quality parameters of these tablets like weight Disintegration test. using an Educational Sciences Disintegration Apparatus USP std. 2°C. USP’s compendia of official documentary drug standards—the United States Pharmacopeia–National Formulary (USP–NF)—contains more than 900 monographs with dissolution, disintegration or drug release requirements. 50 min. 1N Hcl- No disintegration in 120 min With 6. Note the time taken for complete disintegrate in to small particles. Liquefaction time, disintegration time, drop point and particle size was given in Table 2. The USP Dissolution Methods Database contains the test conditions (except Tolerances or Acceptance Criteria) as stated in the sections referring to dissolution, disintegration, or drug release tests in the respective USP drug product monograph. Assay of Paracetamol 20 tablets weighed accurately a quantity of powder equivalent to 0. 8) profile showed a mean release at 30 min of 87% to 97% of label content, with seven brands passing stage-1 (≥ 85% for each of 6 test units) and two passing stage-2 (mean of 12 test units ≥ 85%) criteria. The disintegration time ranged between 6. 2-mm ap-its active constituent. Six Butaproxyvon capsules (Paracetamol 325mg and Diclofenac 50mg) were chosen to determine the disintegration time. 5 min). 11/21/2016 31(2) Second Interim Revision Announcement: <701> DISINTEGRATION As per USP standards, the disintegration time for uncoated tablets is within 15 minutes. 66 defined as that state in which any residue of themm. The average of disintegration time for Formulation 2 was 1 h 28 min. 1 minutes. ; JPRI, 33(29A): 50-57, 2021; Article no. Disintegration of Tablets and Capsules, JP 6. 20C as medium and mean disintegration time was calculated. In Vitro Drug Release Studies. (All dimensions are expressed in mm. Identification— Apparatus 1:100 rpm. 5. 3, 7, [19 the outer beaker that time was noted as disintegration time after that the average time was noted and this process was repeated for all four different brands of paracetamol tablets. The disintegration time was found to be longer compared to the normal tablets. The results are shown in Table 3. 18 One way analysis of variance showed that there was a significant difference in The study concluded that the overall quality of all tested brands of paracetamol was acceptable. 63%, and 01 to Disintegration time and dissolution time were analyzed by disintegration apparatus and dissolution tester respectively. Dissolution At different time intervals, drug release at 10 min was from 17. 11/21/2016 31(2) Second Interim Revision Announcement: <701> DISINTEGRATION 1. 0001). The paracetamol content in suppositories A and C was in the range of ± 6. Disintegra-tion is the break down process of tablet into smaller particles and is the first step towards dissolution. Jun 30, 2021 · Objective To evaluate in-vitro quality of paracetamol 500 mg tablet brands marketed in Saudi Arabia. Both values for the matrix tablet and the disintegration time for the paracetamol both reach the maximum time of 180 s in the Aston test and 1800 s in the USP test for the matrix tablet only Oct 18, 2020 · The disintegration time in 0. Calibration curve by UV Fig. RS. 4 and 9. The time required for the upward stroke is equal to the time required for the downward stroke and the change in stroke direction is a smooth transition rather than an abrupt reversal of texts, Ph. Results: In this study, all the five brands of the tablets passed the BP or USP standards for in vitro evaluation tests with a very slight deviation. 67 ± 3. 0 percent of the labeled amount of A: The retention time of the major peak in the chromato-acetaminophen (C8H9NO2). 78 % and the Jan 30, 2023 · Note: Disintegration time/ Effervescent time (Y 1) and pH value (Y 2) are d ependent variables Table 2 : Compositions of all fo rmulations (F1-F9). 8 buffers and 50 rpm at 37±0 3 days ago · From this average disintegration time was determined. Disintegration time is the key critical quality attribute for a tablet classed as an Orally Disintegrating Tablet (ODT). 00±0. 3 USP 29, <701> Disintegration, pp. [Google Scholar] 129. 17%. Each capsule of Butaproxyvon was inserted in six tubes of disintegration apparatus, the disc was added, and the assembly was suspended in water at 37°C ±0. 89 to 87. 1016/s0928-0987(02)00016-7. Results of weight variation, hardness, friability, and disintegration time ranged from 0. JPRI. Disintegration time for all brands was within 15 minutes also Feb 15, 2022 · The disintegration time ranged from 3. 2. Size of the suspended paracetamol particles was estimated by microscopic observation (light microscope; PZO Studar, Poland) of the suppository mass after melting it on a slide glass in a thin layer and subsequent cooling. com USP 32 Dietary Supplements / 〈2040〉 Disintegration and Dissolution of Dietary Supplements1 782 Apparatus B—The apparatus1 consists of a basket-rack assem-bly, a 1000-mL, low-form beaker for the immersion fluid, a thermo-static arrangement for heating the fluid between 35° and 39°, and a Jul 22, 2021 · Disintegration Test: The USP disintegration apparatus consist of 6 glass tubes that are 3 inches long, open at the top, and held against a 10-mesh screen at the bottom end of the basket rack as-sembly. The disintegration time was taken to be the time no granule of any tablet was left on the mesh of the apparatus. Disintegration test of paracetamol tablets is the devastation process of the tablet into smaller particles when it becomes in contact with body fluid and is the first step towards the dissolution process; this test simulates the disintegration time of the medication in the human body. PARA-6 exhibited the highest disintegration time whereas PARA-7 showed the lowest Oct 1, 2001 · The results demonstrate clearly that essentially complete melting of a suppository in the dissolution chamber is required for an appropriate dissolution of paracetamol in vitro. ) ate the apparatus, using water or the specified medium as Buccal Tablets—Apply the test for Uncoated Tablets. In 18 subjects (75%), onset of disintegration occurred within 5 Feb 20, 2019 · Time in 3 min = Limit 3 min ± 3 sec Time in 15 min = Limit 15 min ± 18 sec ; Time in 30 min = Limit 30 min ± 36 sec ; Time in 60 min = Limit 60 min ± 1 min 12 sec ; Time in 120 min = Limit 120 min ± 2 min 24 sec ; Start the instrument and record the time with calibrated stop watch; Sieve integrity check : Intactness of each sieve opening friability, disintegration time, dissolution test as well as assay content by UV spectrophotometric method. In vitro Paracetamol SR dissolution Disintegration test: Disintegration time is the length of time required for causing disintegration of tablet. 1M NaoH, diluted with 100ml of Various studies conducted in Malaysia, Palestine, Pakistan, Bangladesh, and India have investigated brands of paracetamol and fulfilled the requirements on USP for disintegration time. USP 1-Aug-2019 disintegrate within the prescribed time when placed in a liquid medium at the experimental conditions presented below. Disintegration test The Disintegration time for all the brands of paracetamol tablets must be within 5 mins. Result obtained from disintegration study was found to be within specific limits given in standered books like USP and BP [6] (Figure 2), according to these books disintegration time is Mar 1, 2018 · The 3D printed tablets were evaluated for physical and mechanical properties including weight variation, friability, breaking force, disintegration time, and dimensions and were within acceptable range as defined by the international standards stated in the United States Pharmacopoeia (USP). 1N HCl of paracetamol tablet brands (24 seconds to 4 minutes 52 seconds) were less than the paracetamol/caffeine (6 minutes 33 seconds to 17 minutes 43 seconds) brands. form is for a defined period of time. The average disintegration time for Panadol and Panadol Rapid was 24. These results illustrate that medium viscosity have a greater influence on tablet disintegration for conventional immediate release tablet formulations, CP exemplified by Panodil®, compared preparations that disintegrate rapidly in the oral cavity, with an in-vitro disintegration time of disintegration time. Dietary supplements claimingmaintained at 37± 2°. Based on literature data, a standard conventional paracetamol (CP) tablet, Panodil®, and a rapidly absorbed paracetamol (RP) tablet, Panodil® Zapp, were chosen as model systems to study tablet disintegration in the human stomach. Disintegration apparatus. 1. Eur J Pharm Sci. Four brands were single-drug, containing paracetamol only (R1, G1-G3) and five contained additional active ingredients (R2, G4-G7). 0001; Figure 1). To evaluate the weight variation, hardness, friability, disintegration time, dissolution profile and content uniformity. III. Complete disintegration is a state in which any residue remain is a soft mass having no palpable firm core except fragments of insoluble coating remaining on the screen of the Mar 30, 2023 · The disintegration tests carried out revealed that tablets from F2 showed the shortest disintegration time of 32. 9 vs. 69. Diclofenac Related Compound A RS. After the immersion fluid, maintained at 37±2°. 32 to 100. 18 According to this study the mean disintegration time ranged from 01 minutes to 08 minutes which is less than the standard disintegration time which is 15 minutes for uncoated tablets. 18 One way analysis of variance showed that there was a significant difference in USP Reference Standards 〈11〉—USP Chlorpheniramine of the vessel and the bottom of the basket is maintained at Maleate Extended-Release Tablets RS. At the end of 30 minutes, lift the basket from to be extended-release dosage forms shall not be labeled as in com-the fluid, and observe the tablets: all of the tablets disintegrate com-pliance with USP unless a USP monograph exists for such product. 07 % and at 18 mins 85. Aug 28, 2019 · Both values for the matrix tablet and the disintegration time for the paracetamol both reach the maximum time of 180 s in the Aston test and 1800 s in the USP test for the matrix tablet only Mar 13, 2015 · 7. 8- to 2. 8 and 16. 2 to 150. Each capsule of Butaproxyvon was inserted in six tubes of disintegration apparatus, the disc was added, and the assembly was suspended in water at 37 C Oct 20, 2024 · Disintegration is provided to determine whether tablets, capsules, or granules disintegrate within the prescribed time when placed in a suitable liquid medium in a 1000 ml beaker at 37°C ± 2°C. Therefore Tritt-Goc J, Kowalczuk J. At no time should the top of the basket-rack assembly become submerged. Within 30 minutes, the dissolution profile showed percentage releases ranging from 79. 1 to 65. 7 to 100. 2670-2672. As per the results, both brands A and B conform to the USP standards [6-10]. Drug Disintegration time refers to the period within which a mechanical break-up of compressed tablet dissolve upon exposure to physiological fluids within a short period of time into tiny granules upon ingestion, while drug dissolution rate becomes a key tool in understanding the importance for its bioavailability and therapeutic Disintegration (water medium) time (n = 6, minute: second) ranged from 02:35–03:09 to 12:49–13:10. Tablets from all the formulations released up to 70% of their paracetamol contents within 25 min. 10 to 23±0. 8, maintaining the temperature at 37±20C as. The suppositories A and B showed liquefaction time between 8-10 minutes while = Sep 12, 2018 · According to USP for film-coated tablets, each test tablet should completely be destroyed within a maximum of 30 minutes and 15 minutes as disintegration time for uncoated tablets [20]. 17 ± 0. 7 ± 4. 3. 5 ± 4. The apparatuses 294 〈701〉 Disintegration / Physical Tests USP 35 Figure 1. 67831 53 Fig. 18 According to this study the mean disintegration time ranged from 01 minutes to 08 minutes which is less than the standard disintegration time which is 15 minutes for uncoated tablets. Dec 21, 2020 · Results. Disintegration time. 2002;15(4):341–6. Results: All brands passed USP and BP standards in- vitro quality control tests prescribed for the tablets except hardens test but all products were satisfactory for hardness. USP 1-Aug-2019 Determine the type of units under test from the See full list on pharmacalculation. 1; 10-Jun-2004; Previous Stage 6 posting in PF 31 (2), 2005 (IRA) 2) System suitability solution: 20µg/mL of USP Acet-in the portion of Acetaminophen taken: aminophen RS and 80µg/mL each of USP Acetamino-phen Related Compound B RS and USP Acetamino-Result = (r U/r S) × (C S/C U) × 100 phen Related Compound C RS in Diluent Standard solution: 1. 11%, 117. 11 International Current Pharmaceutical Journal, 2012. 88%. 3, 7, [19 Jun 10, 2004 · The revision to <701> Disintegration General Chapter will be incorporated into and become official with USP 43-NF 38. A: The retention time of the major peak in the chromatogramTimes: 2, 4, 8, and 16 hours. 5 cm below the surface of the liquid on their upward movement and descend not closer than 2. Weight variation (n = 20, range Disintegration is the breakdown process of a tablet into smaller particles and is the first step towards dissolution. Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. As per USP the disintegration apparatus consist of 6 glass tubes with a 10 number mesh at the bottom, each tube is 3 inch long. 63%, and 01 to 08 minutes for all the tablets, respectively. To test for disintegration time, one tablet is placed in each tube and the basket rack is positioned in specified medium at 37 ± 2 Sep 16, 2022 · However, for the RP tablets, all USP 2 based in vitro disintegration setups produced comparable disintegration times to the RP in vivo disintegration time. Disintegration Sep 23, 2018 · For the determination of in vitro release, USP type-II dissolving test apparatus (LAB INDIA DS 8000, India) was used while taking, an intestinal medium with a pH of 6. 5%. The findings show only two brands of paracetamol tablets complied with the disintegration time test, where one brand achieved the shortest time (1. The innovator 4. Dissolution (phosphate buffer, pH 5. Science Division at USP had special meeting to discuss the issue of USP being asked by sponsors to excessively increase upper limits to compensate for stability losses The outcome of that discussion was that USP would avoid for new monographs overages above those already existing in similar monographs currently official at USP, 2021. The standard procedure of performing disintegration test for these dosage forms has several limitations and they do not suffice the measurement of very short disintegration times. The set condition was 900ml of 6. USP Prednisone Tablets 25±2 mm during the test. Eur. Disintegration time, softening time, drop point and particle size of the suspended drug were measured and the relevance of these parameters for dissolution behaviour of Aug 7, 2015 · Various studies conducted in Malaysia, Palestine, Pakistan, Bangladesh, and India have investigated brands of paracetamol and fulfilled the requirements on USP for disintegration time. Aug 3, 2018 · Disintegration time helps us to determine the dissolution and absorption of active drug substance through the body also on the therapeutic efficacy of product. 57 to 0. Disintegration: The disintegration time of all brands of paracetamol was satisfactory and ranged from 56±1. 5% (200 mg tablets) and 1. 3 min, respectively, as can be seen from Figure 3 and Assay preparation— Weigh and finely powder not fewer than 20 Tablets. 15gms of paracetamol and 50ml of 0. Jul 21, 2021 · Aim: This study was performed to evaluate the quality of five brands of Paracetamol 500mg tablets from different manufacturers. 8. The time needed for whole tablet disintegration and passing through sinker's sieve was considered as disintegration time . May 29, 2020 · The tablet disintegration time was determined as the time from the tablet entering the stomach to when it was no longer visible from the camera capsule or when the tablet became fully fragmented. Similarly the 1000-mg PARCOPA tablet product showed the same trend (147 versus 51 s). 27 seconds (figure 4), indicating that all the disintegration rates were within the official limits of 30 minutes (Musa et al. 14 seconds followed by tablets from F5, F3, F4 and F1. To test for disintegration time, one tablet is placed in each tube and the basket rack is positioned in specified medium at 37 ± 2 °C such that tablet remains 2. Aim: This study was performed to evaluate the quality of five brands of Paracetamol 500mg tablets from different manufacturers. The disintegration time was taken to be the time at which no granule of any tablet was left on the meshes of the apparatus . To test for disintegration time, one Feb 15, 2019 · Disintegration is the first physical change observed for a drug when it enters into the body, thus to see simulate the disintegration of the tablet in the body the disintegration test is performed. Dissolution profile of paracetamol in various beverages by UV analysis (modified media Whereas tablets of paracetamol/caffeine A2, B2, C2, D2 and E2 showed higher disintegration time though they also meet the maximum limit of 30 minutes (Banker and Anderson, 2009). Disintegration Test: The USP disintegration apparatus consist of 6 glass tubes that are 3 inches long, open at the top, and held against a 10-mesh screen at the bottom end of the basket rack assembly. In situ, real time observation of the disintegration of paracetamol tablets in aqueous solution by magnetic resonance imaging. Abstract. The release profile of paracetamol from tablets was determined using USP type II dissolution apparatus (PHARMA TEST, PTWS 20D, Germany) at paddle rotation speed of 50 rpm. It is a pharmacopoeial test for the evaluation of tablets or quality control tests of tablets. below the USP-specified limit of < 1. Weight variation (n = 20, range Jun 30, 2021 · Objective To evaluate in-vitro quality of paracetamol 500 mg tablet brands marketed in Saudi Arabia. As per the QC tests performed, the disintegration time for Brand A is 6. 75 % of the label claim, while suppositories C and D were in the range of ± 4. Sep 1, 2001 · Disintegration time, softening time and drop point were studied using procedures and apparatus described in Ph. Sep 1, 2001 · The results demonstrate clearly that essentially complete melting of a suppository in the dissolution chamber is required for an appropriate dissolution of paracetamol in vitro. 10, 11 Dissolution test: Dissolution test is close proximate The quality control parameters which are studied are weight variation test, hardness test, thickness, friability, disintegration and dissolution specified by BP/USP (British and United state Pharmacopoeia) . For the uncoated tablet the disintegration time limit is 15 minutes. 0 percent and not more USP Acetaminophen RS Identification— than 110. Methods: The general quality parameters of these tablets like weight variation, hardness, thickness, diameter, friability, disintegration time and also dissolution time were evaluated according to Aug 28, 2019 · Both values for the matrix tablet and the disintegration time for the paracetamol both reach the maximum time of 180 s in the Aston test and 1800 s in the USP test for the matrix tablet only; Values displayed on the graph have been set at 180 s to represent the maximum. Amount per tablet (mg) Ingredients Jan 21, 2018 · The 3D printed paracetamol tablets were also evaluated for weight variation, hardness, friability, disintegration time, and size and dimension and were within acceptable range as defined by the international standards stated in the USP. doi: 10. 0% (500 mg tablets) on increasing the Paracetamol and Diclofenac potassium was calculated. Transfer an accurately weighed portion of the powder, equivalent to about 100 mg of acetaminophen, to a 200-mL volumetric flask, add about 100 mL of Mobile phase, shake by mechanical means for 10 minutes, sonicate for about 5 minutes, dilute with Mobile phase to volume, and mix. The time for disintegration of ODTs is generally <1 minute and actual disintegration time that patient can experience ranges from 5 to 30 seconds. 6 min, P < 0. Jun 6, 2021 · Figure-3: Tablet Disintegration tester. USP Reference standards 〈11〉— tain not less than 90. Medium and Procedure—Proceed as directed for Test 1. 2. 29, 30 A drug can have a rapid disintegration time but this does not mean the Therefore, the actual disintegration time of ODTs in the oral cavity does not often correlate with the in vitro disintegration time measured by disintegration tests of USP or JP. different brands of paracetamol. 25µg/mL of USP Acetaminophen r Similarly, in the modified USP dissolution test, tablets are placed and suspended in the middle of the container of USP apparatus II (100 rpm, 900 mL, 37°C). Results: From the results, it was observed that all the brands of paracetamol have passed the tests and met the specifications of USP. The overall disintegration time for paracetamol tablet brands was in the ranged from 24 seconds to 4 minutes 52 seconds while paracetamol/caffeine tablet brands ranged Aug 2, 2008 · For example, the disintegration time of 800 mg Zicam tablets using the SWT method was greater than 3 min, which is much closer to in vivo test results, but the USP disintegration time of a Zicam tablet was as fast as 45 s. Six tablets from each brand were tested by 900ml distilled water at 37±0. Disintegration time Six Butaproxyvon capsules (Paracetamol 325mg and Diclofenac 50mg) were chosen to determine the disintegration time. 3, 7, [19 Tablets Disintegration Test Disintegration is about tablets physical beak down and passes through the wire mesh of the tube in disintegration medium in specified time [13]. 0 to 174. To test for disintegration time, one tablet is placed in each tube and the basket rack The purpose of the present study was to study tablet disintegration by direct visualization, in vivo and in vitro. 8 pH phosphate buffer in 60 min: Hard gelatin Additionally , after storage at 40ºC the disintegration time of these brands was within 30 minutes , but for the Paracetamol® and Panda® The results showed that all the brands passed the disintegration test according to USP, which specifies 30 minutes as disintegration time. This is due to the disintegration process that was assumed, happening in the mouth through the chewing mechanism. If any residue remains, it must have a soft mass with no hard core . USP disintegration apparatus containing six glass tubes was used for the purpose. 19. USP Reference standards 〈11〉—USP Diclofenac Sodium RS. 9. All brands were immediate-release. sokmh xdmzc mgkvx hacg qfvzmdw jzoku qiifl xabweyt zyck jrpl